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0 0.5 1 1.5 2+ Mortality 51% Improvement Relative Risk Ventilation 41% Hospitalization 40% c19early.com/mf Wong et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Wong, 39,616 patient metformin prophylaxis study: 51% lower mortality [p<0.0001], 41% lower ventilation [p<0.0001], and 40% lower hospitalization [p<0.0001] https://c19p.org/wong2
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Glycemic Control and Clinical Outcomes in U.S. Patients With COVID-19: Data From the National COVID Cohort Collaborative (N3C) Database
Wong et al., Diabetes Care, doi:10.2337/dc21-2186
24 Feb 2022    Source   PDF   Share   Tweet
N3C retrospective 39,616 COVID-19 patients with diabetes in the USA, showing lower mortality, ventilation, and hospitalization with metformin use.
risk of death, 51.0% lower, HR 0.49, p < 0.001, treatment 10,408, control 29,208, Cox proportional hazards.
risk of mechanical ventilation, 41.0% lower, OR 0.59, p < 0.001, treatment 10,408, control 29,208, adjusted per study, multivariable, RR approximated with OR.
risk of hospitalization, 40.0% lower, OR 0.60, p < 0.001, treatment 10,408, control 29,208, adjusted per study, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wong et al., 2/24/2022, retrospective, USA, North America, peer-reviewed, 15 authors.
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