Wong: Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort

Wong, 1,214 patient metformin prophylaxis study: 59% lower mortality [p=0.01], 61% improved recovery [p=0.005], 64% better improvement [p=0.009], and 56% higher hospital discharge [p=0.009] https://c19p.org/wong

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Metformin Use in Relation to Clinical Outcomes and Hyperinflammatory Syndrome Among COVID-19 Patients With Type 2 Diabetes: A Propensity Score Analysis of a Territory-Wide Cohort

Wong et al., Frontiers in Endocrinology, doi:10.3389/fendo.2022.810914

7 Mar 2022 Source PDF Share Tweet

Retrospective 1,214 COVID+ type 2 diabetes patients in Hong Kong, showing lower mortality and improved recovery with metformin use.

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risk of death, 59.0% lower, OR 0.41, p = 0.01, treatment 786, control 428, adjusted per study, propensity score weighting, multivariable, RR approximated with OR.

risk of no recovery, 60.6% lower, OR 0.39, p = 0.005, treatment 786, control 428, adjusted per study, inverted to make OR<1 favor treatment, propensity score weighting, multivariable, RR approximated with OR.

clinical improvement, 63.5% better, OR 0.36, p = 0.009, treatment 786, control 428, adjusted per study, inverted to make OR<1 favor treatment, propensity score weighting, multivariable, RR approximated with OR.

risk of no hospital discharge, 55.8% lower, OR 0.44, p = 0.009, treatment 786, control 428, adjusted per study, inverted to make OR<1 favor treatment, propensity score weighting, multivariable, RR approximated with OR.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Wong et al., 7 Mar 2022, retrospective, China, peer-reviewed, 11 authors, study period 21 January, 2020 - 31 January, 2021.

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