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0 0.5 1 1.5 2+ Mortality 60% Improvement Relative Risk Ventilation 76% Hospitalization time 34% c19early.com/mf Usman et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Usman, 75 patient metformin prophylaxis study: 60% lower mortality [p=0.21], 76% lower ventilation [p=0.05], and 34% shorter hospitalization [p=0.13] https://c19p.org/usman
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Metformin use in patients hospitalized with COVID-19: lower inflammation, oxidative stress, and thrombotic risk markers and better clinical outcomes
Usman et al., Journal of Thrombosis and Thrombolysis, doi:10.1007/s11239-022-02631-7
18 Jan 2022    Source   PDF   Share   Tweet
Retrospective 75 diabetes patients, 34 on metformin, showing improved clinical outcomes with treatment, without statistical significance.
risk of death, 59.8% lower, RR 0.40, p = 0.21, treatment 3 of 34 (8.8%), control 9 of 41 (22.0%), NNT 7.6.
risk of mechanical ventilation, 75.9% lower, RR 0.24, p = 0.05, treatment 2 of 34 (5.9%), control 10 of 41 (24.4%), NNT 5.4.
hospitalization time, 33.7% lower, relative time 0.66, p = 0.13, treatment 34, control 41.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Usman et al., 1/18/2022, retrospective, USA, North America, peer-reviewed, 10 authors.
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