Agarwal: Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)

Agarwal, 464 patient convalescent plasma late treatment RCT: 7% higher mortality [p=0.74], 7% higher progression [p=0.74], 1% lower ventilation [p=0.98], and 28% improved viral clearance [p=0.02] https://c19p.org/agarwal

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Convalescent plasma in the management of moderate covid-19 in adults in India: open label phase II multicentre randomised controlled trial (PLACID Trial)

Agarwal et al., BMJ, doi:10.1136/bmj.m3939

22 Oct 2020 Source PDF Share Tweet

RCT 464 hospitalized patients in India, 235 treated with convalescent plasma, showing no improvement in combined death at 28 days or progression to severe disease. CTRI/2020/04/024775.

risk of death, 7.0% higher, RR 1.07, p = 0.74, treatment 34 of 235 (14.5%), control 31 of 229 (13.5%).

combined death at 28 days or progression to severe disease, 7.0% higher, RR 1.07, p = 0.74, treatment 44 of 235 (18.7%), control 41 of 229 (17.9%).

risk of mechanical ventilation, 1.0% lower, RR 0.99, p = 0.98, treatment 19 of 227 (8.4%), control 19 of 224 (8.5%), NNT 892.

risk of no viral clearance, 28.0% lower, RR 0.72, p = 0.02, treatment 56 of 173 (32.4%), control 76 of 169 (45.0%), NNT 7.9, day 7.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Agarwal et al., 10/22/2020, Randomized Controlled Trial, India, South Asia, peer-reviewed, 6 authors, average treatment delay 8.0 days.

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This Paper Conv. Plasma All

Late treatment
is less effective

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