9/29 Late treatment study
et al., medRxiv, doi:10.1101/2020.08.26.20182444 (Peer Reviewed)
Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial
Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial
Early terminated RCT with 81 hospitalized patients, 38 treated with convalescent plasma, showing lower progression with treatment. NCT04345523.
Avendaño-Solà et al., 9/29/2020, Randomized Controlled Trial, Spain, Europe, peer-reviewed, 36 authors.
risk of death, 88.3% lower, RR 0.12, p = 0.12, treatment 0 of 38 (0.0%), control 4 of 43 (9.3%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 29.
risk of disease progression, 93.0% lower, RR 0.07, p = 0.01, treatment 0 of 38 (0.0%), control 7 of 43 (16.3%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 29, progression to categories 5-7.
risk of disease progression, 91.9% lower, RR 0.08, p = 0.03, treatment 0 of 38 (0.0%), control 6 of 43 (14.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 15, progression to categories 5-7.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.
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