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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 88% Improvement Relative Risk Progression 93% Progression (b) 92% primary c19early.com/avendanosola.html Favors conv. plasma Favors control
29 September 2020 - Late treatment study
Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial
Avendaño-Solà et al., medRxiv, doi:10.1101/2020.08.26.20182444 (Peer Reviewed)
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Early terminated RCT with 81 hospitalized patients, 38 treated with convalescent plasma, showing lower progression with treatment. NCT04345523.
risk of death, 88.3% lower, RR 0.12, p = 0.12, treatment 0 of 38 (0.0%), control 4 of 43 (9.3%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29.
risk of progression, 93.0% lower, RR 0.07, p = 0.01, treatment 0 of 38 (0.0%), control 7 of 43 (16.3%), NNT 6.1, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29, progression to categories 5-7.
risk of progression, 91.9% lower, RR 0.08, p = 0.03, treatment 0 of 38 (0.0%), control 6 of 43 (14.0%), NNT 7.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 15, progression to categories 5-7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Avendaño-Solà et al., 9/29/2020, Randomized Controlled Trial, Spain, Europe, peer-reviewed, 36 authors, average treatment delay 8.0 days.
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