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0 0.5 1 1.5 2+ Mortality 88% Improvement Relative Risk Progression 93% Progression (b) 92% primary c19early.com/cp Avendaño-Solà et al. NCT04345523 Conv. Plasma RCT LATE Favors conv. plasma Favors control
Avendaño-Solà, 81 patient convalescent plasma late treatment RCT: 88% lower mortality [p=0.12] and 93% lower progression [p=0.01] https://c19p.org/avendanosola
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Convalescent Plasma for COVID-19: A multicenter, randomized clinical trial
Avendaño-Solà et al., medRxiv, doi:10.1101/2020.08.26.20182444
29 Sep 2020    Source   PDF   Share   Tweet
Early terminated RCT with 81 hospitalized patients, 38 treated with convalescent plasma, showing lower progression with treatment. NCT04345523.
risk of death, 88.3% lower, RR 0.12, p = 0.12, treatment 0 of 38 (0.0%), control 4 of 43 (9.3%), NNT 11, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29.
risk of progression, 93.0% lower, RR 0.07, p = 0.01, treatment 0 of 38 (0.0%), control 7 of 43 (16.3%), NNT 6.1, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 29, progression to categories 5-7.
risk of progression, 91.9% lower, RR 0.08, p = 0.03, treatment 0 of 38 (0.0%), control 6 of 43 (14.0%), NNT 7.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 15, progression to categories 5-7, primary outcome.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Avendaño-Solà et al., 9/29/2020, Randomized Controlled Trial, Spain, Europe, peer-reviewed, 36 authors, average treatment delay 8.0 days, trial NCT04345523.
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Late treatment
is less effective
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