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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality -323% Improvement Relative Risk Mortality (b) -114% Mechanical ventilation -221% Hospitalization time 25% Improvement in Ct value 32% c19early.com/bajpai.html Favors conv. plasma Favors control
27 October 2020 - Late treatment study
Efficacy of Convalescent Plasma Therapy compared to Fresh Frozen Plasma in Severely ill COVID-19 Patients: A Pilot Randomized Controlled Trial
Bajpai et al., medRxiv, doi:10.1101/2020.10.25.20219337 (Preprint)
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Small RCT 29 patients in India, 14 treated with convalescent plasma, not showing significant differences with treatment.
risk of death, 323.0% higher, RR 4.23, p = 0.22, treatment 3 of 14 (21.4%), control 1 of 15 (6.7%), adjusted per study, 28 days, Cox proportional hazards.
risk of death, 114.3% higher, RR 2.14, p = 0.60, treatment 2 of 14 (14.3%), control 1 of 15 (6.7%), 7 days.
risk of mechanical ventilation, 221.4% higher, RR 3.21, p = 0.33, treatment 3 of 14 (21.4%), control 1 of 15 (6.7%), 7 days.
hospitalization time, 24.8% lower, relative time 0.75, p = 0.08, treatment 14, control 15.
relative improvement in Ct value, 32.5% better, RR 0.68, p = 0.11, treatment 14, control 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Bajpai et al., 10/27/2020, Randomized Controlled Trial, India, South Asia, preprint, 20 authors.
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