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0 0.5 1 1.5 2+ Mortality 22% Improvement Relative Risk c19early.com/mf Shestakova et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Shestakova, 189,998 patient metformin prophylaxis study: 22% lower mortality [p=0.001] https://c19p.org/shestakova
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Risk factors for COVID-19 case fatality rate in people with type 1 and type 2 diabetes mellitus: A nationwide retrospective cohort study of 235,248 patients in the Russian Federation
Shestakova et al., Frontiers in Endocrinology, doi:10.3389/fendo.2022.909874
9 Aug 2022    Source   PDF   Share   Tweet
Retrospective 224,190 type 2 diabetes patients in Russia, showing lower mortality with metformin use.
risk of death, 21.6% lower, RR 0.78, p = 0.001, treatment 21,471 of 139,637 (15.4%), control 12,721 of 50,361 (25.3%), adjusted per study, odds ratio converted to relative risk, Table S2, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Shestakova et al., 9 Aug 2022, retrospective, Russia, peer-reviewed, 6 authors, study period 20 March, 2020 - 25 November, 2021.
Contact: olga-vikulova-1973@yandex.ru.
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