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0 0.5 1 1.5 2+ Ventilation 54% Improvement Relative Risk ICU admission 56% c19early.com/mf Cousins et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Cousins, 4,995 patient metformin prophylaxis PSM study: 54% lower ventilation [p=0.007] and 56% lower ICU admission [p<0.0001] https://c19p.org/cousinsmf
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Integrative analysis of viral entry networks and clinical outcomes identifies a protective role for spironolactone in severe COVID-19
Cousins et al., medRxiv, doi:10.1101/2022.07.02.22277181 (Preprint)
6 Jul 2022    Source   PDF   Share   Tweet
PSM retrospective 64,349 COVID-19 patients in the USA, showing metformin associated with lower ICU admission and mechanical ventilation.
risk of mechanical ventilation, 54.0% lower, OR 0.46, p = 0.007, treatment 2,498, control 2,497, propensity score matching, RR approximated with OR.
risk of ICU admission, 56.0% lower, OR 0.44, p < 0.001, treatment 2,498, control 2,497, propensity score matching, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Cousins et al., 6 Jul 2022, retrospective, USA, preprint, 8 authors.
Contact: cousinsh@stanford.edu, russ.altman@stanford.edu, yuan.luo@northwestern.edu, congle@stanford.edu.
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