Pahwani, 178 patient famotidine late treatment RCT: 11% lower mortality [p=1], 12% lower ventilation [p=0.73], 10% lower ICU admission [p=0.86], and 17% shorter hospitalization [p<0.0001] https://c19p.org/pahwani
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Efficacy of Oral Famotidine in Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2
et al., Cureus, doi:10.7759/cureus.22404
RCT with 89 famotidine and 89 control patients in Pakistan, showing faster recovery but no significant difference in mortality. 40mg oral famotidine daily.
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risk of death, 11.1% lower, RR 0.89, p = 1.00, treatment 8 of 89 (9.0%), control 9 of 89 (10.1%), NNT 89.
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risk of mechanical ventilation, 12.5% lower, RR 0.88, p = 0.73, treatment 21 of 89 (23.6%), control 24 of 89 (27.0%), NNT 30.
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risk of ICU admission, 10.0% lower, RR 0.90, p = 0.86, treatment 18 of 89 (20.2%), control 20 of 89 (22.5%), NNT 44.
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hospitalization time, 16.5% lower, relative time 0.83, p < 0.001, treatment mean 8.6 (±1.6) n=89, control mean 10.3 (±2.2) n=89.
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recovery time, 9.6% lower, relative time 0.90, p = 0.001, treatment mean 8.5 (±1.7) n=89, control mean 9.4 (±1.9) n=89.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Pahwani et al., 2/20/2022, Randomized Controlled Trial, Pakistan, South Asia, peer-reviewed, mean age 52.0, 8 authors, study period December 2020 - September 2021.
Late treatment
is less effective
is less effective
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