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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Recovery 48% Improvement Relative Risk Recovery (b) 43% Estimated time to 50% r.. 28% c19early.com/fm Brennan et al. NCT04724720 Famotidine RCT EARLY TREATMENT Favors famotidine Favors control
Brennan, 55 patient famotidine early treatment RCT: 48% improved recovery [p=0.23] https://c19p.org/brennan
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Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial
10 Feb 2022    Source   PDF   Share   Tweet
Small RCT with 27 famotidine and 28 placebo patients, showing improved recovery with treatment. Recovery was faster with treatment for 14 of 16 symptoms. There was no mortality or hospitalization. NCT04724720 (history).
risk of no recovery, 48.1% lower, RR 0.52, p = 0.23, treatment 5 of 27 (18.5%), control 10 of 28 (35.7%), NNT 5.8, day 28, ITT.
risk of no recovery, 43.2% lower, RR 0.57, p = 0.34, treatment 4 of 19 (21.1%), control 10 of 27 (37.0%), NNT 6.3, day 28, PP.
estimated time to 50% resolution, 28.1% lower, relative time 0.72, p < 0.01, treatment 27, control 28.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Brennan et al., 10 Feb 2022, Double Blind Randomized Controlled Trial, USA, peer-reviewed, 31 authors, study period January 2021 - April 2021, average treatment delay 4.0 days, trial NCT04724720 (history).
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