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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 47% Improvement Relative Risk Mortality (b) 24% Mortality (c) 85% Mortality (d) 76% c19early.com/ong.html Favors metformin Favors control
30 October 2021 - Prophylaxis study
Association Between Metformin Use and Mortality Among Patients with Type 2 Diabetes Mellitus Hospitalized for COVID-19 Infection
Ong et al., Journal of the ASEAN Federation of Endocrine Societies, doi:10.15605/jafes.036.02.20 (Peer Reviewed)
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Retrospective 355 diabetic hospitalized COVID-19 patients in the Philippines, showing lower mortality with metformin use.
risk of death, 46.8% lower, RR 0.53, p = 0.02, treatment 33 of 186 (17.7%), control 57 of 169 (33.7%), NNT 6.3, adjusted per study, odds ratio converted to relative risk, combined pre-existing and in-hospital use.
risk of death, 23.9% lower, RR 0.76, p = 0.16, treatment 28 of 109 (25.7%), control 57 of 169 (33.7%), NNT 12, odds ratio converted to relative risk, pre-existing use, unadjusted.
risk of death, 85.2% lower, RR 0.15, p = 0.002, treatment 2 of 40 (5.0%), control 57 of 169 (33.7%), NNT 3.5, odds ratio converted to relative risk, in-hospital use, unadjusted.
risk of death, 76.0% lower, RR 0.24, p = 0.005, treatment 3 of 37 (8.1%), control 57 of 169 (33.7%), NNT 3.9, odds ratio converted to relative risk, mixed pre-existing/in-hospital use, unadjusted.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Ong et al., 10/30/2021, retrospective, Philippines, Asia, peer-reviewed, 6 authors, study period 1 March, 2020 - 30 September, 2020.
Contact: anj0321ong@gmail.com.
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