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0 0.5 1 1.5 2+ Mortality 60% Improvement Relative Risk Ventilation 76% c19early.com/mf Bliden et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Bliden, 75 patient metformin prophylaxis study: 60% lower mortality [p=0.21] and 76% lower ventilation [p=0.05] https://c19p.org/bliden
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Metformin Use in Patients Hospitalized With COVID-19: Lower Inflammation, Oxidative Stress, and Thrombotic Risk Markers and Better Clinical Outcomes
Bliden et al., Circulation, 144:A12228 (Preprint)
8 Nov 2021    Source   PDF   Share   Tweet
Retrospective 75 diabetes patients, 34 on metformin, showing lower mortality with treatment in unadjusted results with minimal group details.
risk of death, 59.8% lower, RR 0.40, p = 0.21, treatment 3 of 34 (8.8%), control 9 of 41 (22.0%), NNT 7.6.
risk of mechanical ventilation, 75.9% lower, RR 0.24, p = 0.05, treatment 2 of 34 (5.9%), control 10 of 41 (24.4%), NNT 5.4.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: unadjusted results with minimal group details.
Bliden et al., 11/8/2021, retrospective, USA, North America, preprint, 9 authors.
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