All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
et al., Viruses, doi:10.3390/v13081669 (In Vitro)
In Vitro and In Silico study showing that all-trans retinoic acid is a potent SARS-CoV-2 3CLpro inhibitor, inhibits SARS-CoV-2 replication in VeroE6/TMPRSS2 cells, and is effective against alpha, beta, gamma, and delta variants in Calu-3 cells.
Morita et al., 8/23/2021, peer-reviewed, 9 authors.
In Vitro studies are an important part of preclinical research, however results may be very different in vivo.
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