Prospective analysis of 40 hospitalized patients and 47 age-matched convalescent patients, showing significantly lower vitamin A levels in critical patients, and significantly lower vitamin A levels in hospitalized patients vs. controls. Low vitamin A levels were significantly associated with ARDS and mortality in hospitalized patients.
Tepasse et al., 6/24/2021, prospective, Germany, Europe, peer-reviewed, 8 authors.
risk of death, 69.7% lower, RR 0.30, p = 0.04, treatment 4 of 29 (13.8%), control 5 of 11 (45.5%), odds ratio converted to relative risk, >2mg/L, logistic regression.
risk of disease progression, 45.2% lower, RR 0.55, p = 0.05, treatment 13 of 29 (44.8%), control 9 of 11 (81.8%), odds ratio converted to relative risk, progression to ARDS, >2mg/L, logistic regression.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.