24 June 2021 - Analysis of outcomes based on serum levels
Vitamin A Plasma Levels in COVID-19 Patients: A Prospective Multicenter Study and Hypothesis
et al., Nutrients, doi:10.3390/nu13072173 (Peer Reviewed)
Prospective analysis of 40 hospitalized patients and 47 age-matched convalescent patients, showing significantly lower vitamin A levels in critical patients, and significantly lower vitamin A levels in hospitalized patients vs. controls. Low vitamin A levels were significantly associated with ARDS and mortality in hospitalized patients.
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risk of death, 69.7% lower, RR 0.30, p = 0.04, treatment 4 of 29 (13.8%), control 5 of 11 (45.5%), NNT 3.2, odds ratio converted to relative risk, >2mg/L, logistic regression.
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risk of progression, 45.2% lower, RR 0.55, p = 0.048, treatment 13 of 29 (44.8%), control 9 of 11 (81.8%), NNT 2.7, odds ratio converted to relative risk, progression to ARDS, >2mg/L, logistic regression.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. |
Tepasse et al., 6/24/2021, prospective, Germany, Europe, peer-reviewed, 8 authors.
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