Clinical efficacy of casirivimab-imdevimab antibody combination treatment in patients with COVID-19 Delta variant
MD Naoyuki Miyashita, Yasushi Nakamori, Makoto Ogata, Naoki Fukuda, Akihisa Yamura, Yoshihisa Ishiura
Journal of Infection and Chemotherapy, doi:10.1016/j.jiac.2022.05.012
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Conflicts of interest The authors declare that they have no conflicts of interest.
Author's contributions: All the authors conceived the study, participated in its design and coordination and collected and managed the data, including quality control. NM and YN drafted the manuscript, and all authors contributed substantially to its revision. All the authors read and approved the final manuscript.
Ethical approval and consent to participate J o u r n a l P r e -p r o o f
References
Baum, Fulton, Wloga, Copin, Pascal et al., Antibody cocktail to SARS-CoV-2 spike protein prevents rapid mutational escape seen with individual antibodies, Science
Bierle, Ganesh, Razonable, Breakthrough COVID-19 and casirivimabimdevimab treatment during a SARS-CoV-2 B1.617.2 (Delta) surge, J Clin Virol
Ghosn, Chaimani, Evrenoglou, Davidson, Graña et al., Interleukin-6 blocking agents for treating COVID-19: a living systematic review, Cochrane Database Syst Rev
Hansen, Baum, Pascal, Russo, Giordano et al., Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail, Science
Marconi, Ramanan, De Bono, Kartman, Krishnan et al., Efficacy and safety of baricitinib for the treatment of hospitalised adults with COVID-19 (COV-BARRIER): a randomised, double-blind, parallel-group, placebocontrolled phase 3 trial, Lancet Respir Med
O'brien, Forleo-Neto, Musser, Chan, Sarkar, Subcutaneous REGEN-COV antibody combination to prevent Covid-19, N Engl J Med
O'brien, Forleo-Neto, Sarkar, Isa, Hou et al., Effect of subcutaneous casirivimab and imdevimab antibody combination vs placebo on J o u r n a l P r e -p r o o f development of symptomatic COVID-19 in early asymptomatic SARS-CoV-2 infection. A Randomized Clinical Trial, JAMA
Planas, Saunders, Maes, Guivel-Benhassine, Planchais et al., Considerable escape of SARS-CoV-2 Omicron to antibody neutralization, Nature
Siemieniuk, Bartoszko, Ge, Zeraatkar, Izcovich et al., Drug treatments for covid-19: living systematic review and network meta-analysis, BMJ
Takashita, Kinoshita, Yamayoshi, Sakai-Tagawa, Fujisaki et al., Efficacy of Antibodies and Antiviral Drugs against Covid-19 Omicron Variant, N Engl J Med
Takashita, Kinoshita, Yamayoshi, Sakai-Tagawa, Fujisaki et al., Efficacy of antiviral agents against the SARS-CoV-2 Omicron subvariant BA.2, N Engl J Med Mar,
doi:10.1056/NEJMc2201933Wagner, Griesel, Mikolajewska, Mueller, Nothacker et al., Systemic corticosteroids for the treatment of COVID-19, Cochrane Database Syst Rev
Weinreich, Sivapalasingam, Norton, Ali, Gao et al., REGEN-COV antibody combination and outcomes in outpatients with Covid-19, N Engl J Med
Weinreich, Sivapalasingam, Norton, Ali, Gao et al., REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19, N Engl J Med
Zhu, Zhang, Li, Yang, Song, A novel coronavirus from patients with pneumonia in China, 2019, N Engl J Med
