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0 0.5 1 1.5 2+ ICU admission 31% Improvement Relative Risk Oxygen therapy 7% Hospitalization -108% c19regn.com Levey et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Levey, 86 patient casirivimab/imdevimab early treatment study: 108% higher hospitalization [p=0.15] https://c19p.org/levey
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Outcomes of pregnant patients treated with REGEN-COV during the COVID-19 pandemic
Levey et al., American Journal of Obstetrics & Gynecology MFM, doi:10.1016/j.ajogmf.2022.100673
4 Jun 2022    Source   PDF   Share   Tweet
Retrospective 86 pregnant COVID-19 patients, 36 treated with casirivimab/imdevimab, showing no significant difference in COVID-19 outcomes with treatment.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of ICU admission, 30.6% lower, RR 0.69, p = 1.00, treatment 1 of 36 (2.8%), control 2 of 50 (4.0%), NNT 82.
risk of oxygen therapy, 7.4% lower, RR 0.93, p = 1.00, treatment 2 of 36 (5.6%), control 3 of 50 (6.0%), NNT 225.
risk of hospitalization, 108.3% higher, RR 2.08, p = 0.15, treatment 9 of 36 (25.0%), control 6 of 50 (12.0%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Levey et al., 4 Jun 2022, retrospective, USA, peer-reviewed, 6 authors, study period March 2021 - October 2021.
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