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0 0.5 1 1.5 2+ Death/hospitalization -15% Improvement Relative Risk Death/hospitalization (b) -29% Death/hospitalization (c) -75% late c19early.com/ace Lapi et al. Acetaminophen for COVID-19 EARLY TREATMENT Favors acetaminophen Favors control
Lapi, acetaminophen early treatment study: 15% higher combined mortality/hospitalization [p=0.22] https://c19p.org/lapi
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To clarify the safety profile of paracetamol for home-care patients with COVID-19: a real-world cohort study, with nested case–control analysis, in primary care
Lapi et al., Internal and Emergency Medicine, doi:10.1007/s11739-022-03054-1
30 Jul 2022    Source   PDF   Share   Tweet
Retrospective paracetamol use with a primary care database in Italy, showing no significant difference in hospitalization/death for use 0-3 and 4-7 days from diagnosis, and significantly higher risk for use >7 days from diagnosis. Confounding by indication may have a greater effect on late usage.
risk of death/hospitalization, 15.0% higher, OR 1.15, p = 0.22, adjusted per study, early use, RR approximated with OR.
risk of death/hospitalization, 29.0% higher, OR 1.29, p = 0.52, adjusted per study, mid-term use, RR approximated with OR.
risk of death/hospitalization, 75.0% higher, OR 1.75, p < 0.001, adjusted per study, late use, RR approximated with OR, late treatment result, excluded in exclusion analyses: substantial unadjusted confounding by indication likely.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lapi et al., 30 Jul 2022, retrospective, Italy, peer-reviewed, 8 authors.
Contact: lapi.francesco@simg.it.
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