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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization -5% Improvement Relative Risk Case 3% c19early.com/ace Xie et al. Acetaminophen for COVID-19 Prophylaxis Favors acetaminophen Favors ibuprofen
Xie, 1,370,600 patient acetaminophen prophylaxis study: 5% higher hospitalization [p=0.83] and 3% fewer cases [p=0.82] https://c19p.org/xie
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Risk of COVID-19 Diagnosis and Hospitalization in Patients with Osteoarthritis or Back Pain Treated with Ibuprofen Compared to Other NSAIDs or Paracetamol: A Network Cohort Study
Xie et al., SSRN Electronic Journal, doi:10.2139/ssrn.4161710
13 Jul 2022    Source   PDF   Share   Tweet
PSM retrospective 1,370,600 osteoarthritis or back pain patients in the US, showing no significant differences in COVID-19 cases and hospitalization for paracetamol vs. ibuprofen.
risk of hospitalization, 4.8% higher, HR 1.05, p = 0.83, inverted to make RR<1 favor treatment, Open Claims, PharMetrics Plus, both periods combined.
risk of case, 3.5% lower, HR 0.97, p = 0.82, inverted to make RR<1 favor treatment, Open Claims, PharMetrics Plus, both periods combined.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Xie et al., 13 Jul 2022, retrospective, USA, peer-reviewed, 9 authors, study period 1 February, 2020 - 31 October, 2020, this trial compares with another treatment - results may be better when compared to placebo.
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