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0 0.5 1 1.5 2+ Mortality 21% Improvement Relative Risk Case -18% c19early.com/aa Kwon et al. Antiandrogens for COVID-19 Prophylaxis Favors antiandrogen Favors control
Kwon, 5,211 patient various antiandrogen prophylaxis study: 21% lower mortality [p=1] and 18% more cases [p=0.54] https://c19p.org/kwon
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Androgen-deprivation therapy and SARS-CoV-2 in men with prostate cancer: findings from the University of California Health System registry
Kwon et al., Annals of Oncology, doi:10.1016/j.annonc.2021.01.067
29 Jan 2021    Source   PDF   Share   Tweet
Retrospective 5,211 prostate cancer patients, 799 on ADT, showing no significant differences in COVID-19 outcomes with treatment.
risk of death, 21.1% lower, RR 0.79, p = 1.00, treatment 1 of 799 (0.1%), control 7 of 4,412 (0.2%), NNT 2985.
risk of case, 17.6% higher, RR 1.18, p = 0.54, treatment 18 of 799 (2.3%), control 79 of 4,412 (1.8%), adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kwon et al., 1/29/2021, retrospective, USA, North America, peer-reviewed, 7 authors.
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