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Antiandrogen study #8   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Recovery 62% Imp. Relative Risk, 95% CI Recovery time 44% Recovery time (b) 40% Cadegiani: Early Antiandrogen Therapy With Dutasteride Reduces Vira.. c19early.com/cadegiani7.html Favors antiandrogen Favors control
2/1 Early treatment study
Cadegiani et al., Cureus, doi:10.7759/cureus.13047 (Peer Reviewed)
Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical)
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RCT 130 outpatients in Brazil, 54 treated with dutasteride, showing faster recovery with treatment. All patients received nitazoxanide. There were no hospitalizations, mechanical ventilation, or deaths. 34110420.2.0000.0008. Some percentages for viral clearance in Table 3 do not match the group sizes, and John Carlisle's "Table 1" analysis suggests possible randomization failure.
risk of no recovery, 62.0% lower, RR 0.38, p = 0.009, treatment 7 of 44 (15.9%), control 18 of 43 (41.9%).
recovery time, 43.6% lower, relative time 0.56, p < 0.001, treatment 44, control 43, all symptoms.
recovery time, 40.2% lower, relative time 0.60, p < 0.001, treatment 44, control 43, all symptoms except loss of smell or taste.
This study is excluded in the after exclusion results of meta analysis: potential randomization failure.
Cadegiani et al., 2/1/2021, Double Blind Randomized Controlled Trial, Brazil, South America, peer-reviewed, 4 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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