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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Recovery 62% Improvement Relative Risk Recovery time 44% Recovery time (b) 40% c19early.com/aa Cadegiani et al. Antiandrogens for COVID-19 RCT EARLY Favors antiandrogen Favors control
Cadegiani, 87 patient dutasteride antiandrogen early treatment RCT: 62% improved recovery [p=0.009] https://c19p.org/cadegiani7
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Early Antiandrogen Therapy With Dutasteride Reduces Viral Shedding, Inflammatory Responses, and Time-to-Remission in Males With COVID-19: A Randomized, Double-Blind, Placebo-Controlled Interventional Trial (EAT-DUTA AndroCoV Trial – Biochemical)
Cadegiani et al., Cureus, doi:10.7759/cureus.13047
1 Feb 2021    Source   PDF   Share   Tweet
RCT 130 outpatients in Brazil, 54 treated with dutasteride, showing faster recovery with treatment. All patients received nitazoxanide. There were no hospitalizations, mechanical ventilation, or deaths. Some percentages for viral clearance in Table 3 do not match the group sizes, and a third-party analysis suggests possible randomization failure. 34110420.2.0000.0008.
risk of no recovery, 62.0% lower, RR 0.38, p = 0.009, treatment 7 of 44 (15.9%), control 18 of 43 (41.9%), NNT 3.9.
recovery time, 43.6% lower, relative time 0.56, p < 0.001, treatment 44, control 43, all symptoms.
recovery time, 40.2% lower, relative time 0.60, p < 0.001, treatment 44, control 43, all symptoms except loss of smell or taste.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: potential randomization failure.
Cadegiani et al., 2/1/2021, Double Blind Randomized Controlled Trial, Brazil, South America, peer-reviewed, 4 authors.
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