Kotfis, 49 patient potassium canrenoate antiandrogen late treatment RCT: 17% lower mortality [p=1], 11% lower ICU admission [p=1], and 30% improved recovery [p=0.51] https://c19p.org/kotfis
copied to clipboard
Mineralocorticoid Receptor Antagonist (Potassium Canrenoate) Does Not Influence Outcome in the Treatment of COVID-19-Associated Pneumonia and Fibrosis—A Randomized Placebo Controlled Clinical Trial
et al., Pharmaceuticals, doi:10.3390/ph15020200
RCT with 24 patients treated with potassium canrenoate and 25 placebo patients in Poland, showing no significant differences.
|
risk of death, 16.7% lower, RR 0.83, p = 1.00, treatment 4 of 24 (16.7%), control 5 of 25 (20.0%), NNT 30.
|
|
risk of ICU admission, 10.7% lower, RR 0.89, p = 1.00, treatment 6 of 24 (25.0%), control 7 of 25 (28.0%), NNT 33.
|
|
relative TFS score, 30.4% better, RR 0.70, p = 0.51, treatment 24, control 25.
|
| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Kotfis et al., 2/5/2022, Randomized Controlled Trial, placebo-controlled, Poland, Europe, peer-reviewed, 10 authors, study period December 2020 - August 2021, trial NCT04912011.
Contact:
katarzyna.kotfis@pum.edu.pl (corresponding author), igor.karolak@gmail.com, kacper.lechowicz@gmail.com, mazegan@wp.pl, apikulska@wp.pl, paulina.niedzwiedzka-rystwej@usz.edu.pl, kawamilosz@gmail.com, jsien@poczta.onet.pl, aleksandra.szylinska@gmail.com, mwisniewska35@gmail.com.
Late treatment
is less effective
is less effective
Please send us corrections, updates, or comments. Vaccines and
treatments are both valuable and complementary. All practical, effective, and
safe means should be used. No treatment, vaccine, or intervention is 100%
available and effective for all current and future variants. Denying the
efficacy of any method increases mortality, morbidity, collateral damage, and
the risk of endemic status. We do not provide medical advice. Before taking
any medication, consult a qualified physician who can provide personalized
advice and details of risks and benefits based on your medical history and
situation. FLCCC and WCH
provide treatment protocols.