Kotfis: Mineralocorticoid Receptor Antagonist (Potassium Canrenoate) Does Not Influence Outcome in the Treatment of COVID-19-Associated Pneumonia and Fibrosis—A Randomized Placebo Controlled Clinical Trial

Kotfis, 49 patient potassium canrenoate antiandrogen late treatment RCT: 17% lower mortality [p=1], 11% lower ICU admission [p=1], and 30% improved recovery [p=0.51] https://c19p.org/kotfis

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Mineralocorticoid Receptor Antagonist (Potassium Canrenoate) Does Not Influence Outcome in the Treatment of COVID-19-Associated Pneumonia and Fibrosis—A Randomized Placebo Controlled Clinical Trial

Kotfis et al., Pharmaceuticals, doi:10.3390/ph15020200, NCT04912011 (history)

5 Feb 2022 Source PDF Share Tweet

RCT with 24 patients treated with potassium canrenoate and 25 placebo patients in Poland, showing no significant differences.

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risk of death, 16.7% lower, RR 0.83, p = 1.00, treatment 4 of 24 (16.7%), control 5 of 25 (20.0%), NNT 30.

risk of ICU admission, 10.7% lower, RR 0.89, p = 1.00, treatment 6 of 24 (25.0%), control 7 of 25 (28.0%), NNT 33.

relative TFS score, 30.4% better, RR 0.70, p = 0.51, treatment 24, control 25.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Kotfis et al., 5 Feb 2022, Randomized Controlled Trial, placebo-controlled, Poland, peer-reviewed, 10 authors, study period December 2020 - August 2021, trial NCT04912011 (history).

Contact: katarzyna.kotfis@pum.edu.pl (corresponding author), igor.karolak@gmail.com, kacper.lechowicz@gmail.com, mazegan@wp.pl, apikulska@wp.pl, paulina.niedzwiedzka-rystwej@usz.edu.pl, kawamilosz@gmail.com, jsien@poczta.onet.pl, aleksandra.szylinska@gmail.com, mwisniewska35@gmail.com.

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This Paper Antiandrogens All

Late treatment
is less effective

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