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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 55% Improvement Relative Risk Ventilation 34% ICU admission 19% Recovery 47% c19early.com/aa Abbasi et al. Antiandrogens for COVID-19 RCT LATE Favors antiandrogen Favors control
Abbasi, 138 patient spironolactone antiandrogen late treatment RCT: 55% lower mortality [p=0.1], 34% lower ventilation [p=0.36], 19% lower ICU admission [p=0.67], and 47% improved recovery [p<0.0001] https://c19p.org/abbasi
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A Randomized Trial of Sitagliptin and Spironolactone With Combination Therapy in Hospitalized Adults With COVID-19
Abbasi et al., Journal of the Endocrine Society, doi:10.1210/jendso/bvac017
7 Feb 2022    Source   PDF   Share   Tweet
RCT including 51 spironolactone patients and 87 control patients in Iran, showing improved recovery with spironolactone, sitagliptin, and the combination of both.
risk of death, 55.1% lower, RR 0.45, p = 0.10, treatment 5 of 51 (9.8%), control 19 of 87 (21.8%), NNT 8.3, day 5.
risk of mechanical ventilation, 33.7% lower, RR 0.66, p = 0.36, treatment 7 of 51 (13.7%), control 18 of 87 (20.7%), NNT 14, day 5.
risk of ICU admission, 18.8% lower, RR 0.81, p = 0.67, treatment 10 of 51 (19.6%), control 21 of 87 (24.1%), NNT 22, day 5.
risk of no recovery, 47.3% lower, RR 0.53, p < 0.001, treatment mean 1.64 (±0.81) n=51, control mean 3.11 (±2.45) n=87, relative clinical score, day 5.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Abbasi et al., 2/7/2022, Single Blind Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 11 authors, study period December 2020 - April 2021.
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Late treatment
is less effective
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