Abbasi, 138 patient spironolactone antiandrogen late treatment RCT: 55% lower mortality [p=0.1], 34% lower ventilation [p=0.36], 19% lower ICU admission [p=0.67], and 47% improved recovery [p<0.0001] https://c19p.org/abbasi
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A Randomized Trial of Sitagliptin and Spironolactone With Combination Therapy in Hospitalized Adults With COVID-19
et al., Journal of the Endocrine Society, doi:10.1210/jendso/bvac017
RCT including 51 spironolactone patients and 87 control patients in Iran, showing improved recovery with spironolactone, sitagliptin, and the combination of both.
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risk of death, 55.1% lower, RR 0.45, p = 0.10, treatment 5 of 51 (9.8%), control 19 of 87 (21.8%), NNT 8.3, day 5.
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risk of mechanical ventilation, 33.7% lower, RR 0.66, p = 0.36, treatment 7 of 51 (13.7%), control 18 of 87 (20.7%), NNT 14, day 5.
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risk of ICU admission, 18.8% lower, RR 0.81, p = 0.67, treatment 10 of 51 (19.6%), control 21 of 87 (24.1%), NNT 22, day 5.
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risk of no recovery, 47.3% lower, RR 0.53, p < 0.001, treatment mean 1.64 (±0.81) n=51, control mean 3.11 (±2.45) n=87, relative clinical score, day 5.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Abbasi et al., 2/7/2022, Single Blind Randomized Controlled Trial, Iran, Middle East, peer-reviewed, 11 authors, study period December 2020 - April 2021.
Late treatment
is less effective
is less effective
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