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0 0.5 1 1.5 2+ Mortality -124% Improvement Relative Risk Case 7% c19early.com/aa Klein et al. Antiandrogens for COVID-19 Prophylaxis Favors various Favors control
Klein, 1,779 patient various antiandrogen prophylaxis study: 124% higher mortality [p=0.12] and 7% fewer cases [p=0.8] https://c19p.org/klein
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Androgen Deprivation Therapy in Men with Prostate Cancer Does Not Affect Risk of Infection with SARS-CoV-2
Klein et al., Journal of Urology, doi:10.1097/JU.0000000000001338
1 Feb 2021    Source   PDF   Share   Tweet
Retrospective 1,779 prostate cancer patients, showing no significant differences in COVID-19 outcomes with ADT.
risk of death, 123.9% higher, RR 2.24, p = 0.12, treatment 6 of 304 (2.0%), control 13 of 1,475 (0.9%).
risk of case, 6.6% lower, RR 0.93, p = 0.80, treatment 17 of 304 (5.6%), control 85 of 1,475 (5.8%), NNT 586, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Klein et al., 1 Feb 2021, retrospective, USA, peer-reviewed, 7 authors, study period 12 March, 2020 - 10 June, 2020.
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