Gomaa: Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial

Gomaa, 50 patient glycyrrhizin antiandrogen late treatment RCT: 91% lower mortality [p=0.05], 91% lower ventilation [p=0.05], and 44% faster recovery [p=0.001] https://c19p.org/gomaa

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Advancing combination treatment with glycyrrhizin and boswellic acids for hospitalized patients with moderate COVID-19 infection: a randomized clinical trial

Gomaa et al., Inflammopharmacology, doi:10.1007/s10787-022-00939-7, NCT04487964 (history)

1 Mar 2022 Source PDF Share Tweet

RCT with 50 hospitalized COVID+ patients in Egypt, 25 treated with glycyrrhizin and boswellic acid, showing improved recovery with treatment. Glycyrrhizin 60mg and boswellic acid 200mg bid for 2 weeks. NCT04487964 (history).

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risk of death, 90.9% lower, RR 0.09, p = 0.05, treatment 0 of 25 (0.0%), control 5 of 25 (20.0%), NNT 5.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14.

risk of mechanical ventilation, 90.9% lower, RR 0.09, p = 0.05, treatment 0 of 25 (0.0%), control 5 of 25 (20.0%), NNT 5.0, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 14.

recovery time, 44.0% lower, relative time 0.56, p < 0.001, treatment 25, control 25.

risk of no recovery, 33.3% lower, RR 0.67, p < 0.001, treatment 25, control 25, relative clinical status, day 14.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Gomaa et al., 1 Mar 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Egypt, peer-reviewed, median age 60.0, 5 authors, study period June 2021 - November 2021, average treatment delay 6.0 days, this trial uses multiple treatments in the treatment arm (combined with boswellic acid) - results of individual treatments may vary, trial NCT04487964 (history).

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This Paper Antiandrogens All

Late treatment
is less effective

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