Lee, 39,153 patient various antiandrogen prophylaxis study: 21% lower severe cases [p=0.03] and 11% fewer cases [p=0.001] https://c19p.org/lee5
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A population-level analysis of the protective effects of androgen deprivation therapy against COVID-19 disease incidence and severity
et al., Frontiers in Medicine, doi:10.3389/fmed.2022.774773
Retrospective 3,057 androgen deprivation therapy patients in the USA, and 36,096 control patients with cancer, showing lower risk of cases and severity with ADT.
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risk of severe case, 21.4% lower, RR 0.79, p = 0.03, treatment 76 of 295 (25.8%), control 727 of 2,427 (30.0%), NNT 24, adjusted per study, odds ratio converted to relative risk, propensity score weighting, multivariable.
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risk of case, 11.3% lower, RR 0.89, p < 0.001, treatment 295 of 3,057 (9.6%), control 2,427 of 36,096 (6.7%), adjusted per study, odds ratio converted to relative risk, propensity score weighting, multivariable.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Lee et al., 7 Mar 2022, retrospective, USA, peer-reviewed, 14 authors, study period 15 February, 2020 - 15 July, 2020.
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