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0 0.5 1 1.5 2+ Severe case 21% Improvement Relative Risk Case 11% c19early.com/aa Lee et al. Antiandrogens for COVID-19 Prophylaxis Favors various Favors control
Lee, 39,153 patient various antiandrogen prophylaxis study: 21% lower severe cases [p=0.03] and 11% fewer cases [p=0.001] https://c19p.org/lee5
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A population-level analysis of the protective effects of androgen deprivation therapy against COVID-19 disease incidence and severity
Lee et al., Frontiers in Medicine, doi:10.3389/fmed.2022.774773
7 Mar 2022    Source   PDF   Share   Tweet
Retrospective 3,057 androgen deprivation therapy patients in the USA, and 36,096 control patients with cancer, showing lower risk of cases and severity with ADT.
risk of severe case, 21.4% lower, RR 0.79, p = 0.03, treatment 76 of 295 (25.8%), control 727 of 2,427 (30.0%), NNT 24, adjusted per study, odds ratio converted to relative risk, propensity score weighting, multivariable.
risk of case, 11.3% lower, RR 0.89, p < 0.001, treatment 295 of 3,057 (9.6%), control 2,427 of 36,096 (6.7%), adjusted per study, odds ratio converted to relative risk, propensity score weighting, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lee et al., 7 Mar 2022, retrospective, USA, peer-reviewed, 14 authors, study period 15 February, 2020 - 15 July, 2020.
Contact: rhauger@health.ucsd.edu, mrettig@mednet.ucla.edu.
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