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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Hospitalization 70% Improvement Relative Risk c19early.com/epicsr.html Favors paxlovid Favors control
14 December 2021 - Early treatment study
Pfizer announces additional phase 2/3 study results confirming robust efficacy of novel COVID-19 oral antiviral treatment candidate in reducing risk or hospitalization or death
Pfizer Press Release (News)
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EPIC-SR trial interim results, 428 patients treated with paxlovid (PF-07321332 + ritonavir) and 426 control patients, showing lower hospitalization with treatment. NCT05011513.
risk of hospitalization, 70.1% lower, RR 0.30, p = 0.05, treatment 3 of 428 (0.7%), control 10 of 426 (2.3%), NNT 61. With the observed event rates, ~23 more patients per arm would result in statistical significance.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Pfizer et al., 12/14/2021, Double Blind Randomized Controlled Trial, multiple countries, multiple regions, preprint, 1 author.
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