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Antiandrogen study #6   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Recovery time 77% Imp. Relative Risk, 95% CI Recovery time (b) 83% Time to viral- 38% Cadegiani: An open-label prospective observational study of antiand.. c19early.com/cadegiani9.html Favors antiandrogen Favors control
10/6 Early treatment study
Cadegiani et al., medRxiv, doi:10.1101/2020.10.05.20206870 (Preprint)
An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial
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Prospective study of 270 female COVID-19 patients in Brazil, 75 with hyperandrogenism, of which 8 were on spiralactone. Results suggest that HA patients may be at increased risk, and that spironolactone use may reduce the risk compared to both other HA patients and non-HA patients. SOC included other treatments and there was no mortality or hospitalization.
recovery time, 76.7% lower, relative time 0.23, p = 0.006, treatment 8, control 262, excluding anosmia.
recovery time, 82.8% lower, relative time 0.17, p = 0.002, treatment 8, control 262, including anosmia.
time to viral-, 37.9% lower, relative time 0.62, p = 0.02, treatment 8, control 262.
This study is excluded in the after exclusion results of meta analysis: significant unadjusted differences between groups.
Cadegiani et al., 10/6/2020, prospective, Brazil, South America, preprint, 4 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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