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0 0.5 1 1.5 2+ Recovery time 77% Improvement Relative Risk Recovery time (b) 83% Time to viral- 38% c19early.com/aa Cadegiani et al. Antiandrogens for COVID-19 EARLY Favors antiandrogen Favors control
Cadegiani, 270 patient spironolactone antiandrogen early treatment study: 77% faster recovery [p=0.006] and 38% faster viral clearance [p=0.02] https://c19p.org/cadegiani9
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An open-label prospective observational study of antiandrogen and non-antiandrogen early pharmacological approaches in females with mild-to-moderate COVID-19. The Pre-AndroCoV Female Trial
Cadegiani et al., medRxiv, doi:10.1101/2020.10.05.20206870 (Preprint)
6 Oct 2020    Source   PDF   Share   Tweet
Prospective study of 270 female COVID-19 patients in Brazil, 75 with hyperandrogenism, of which 8 were on spironolactone. Results suggest that HA patients may be at increased risk, and that spironolactone use may reduce the risk compared to both other HA patients and non-HA patients. SOC included other treatments and there was no mortality or hospitalization.
recovery time, 76.7% lower, relative time 0.23, p = 0.006, treatment 8, control 262, excluding anosmia.
recovery time, 82.8% lower, relative time 0.17, p = 0.002, treatment 8, control 262, including anosmia.
time to viral-, 37.9% lower, relative time 0.62, p = 0.02, treatment 8, control 262.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in the after exclusion results of meta analysis: significant unadjusted differences between groups.
Cadegiani et al., 10/6/2020, prospective, Brazil, South America, preprint, 4 authors, average treatment delay 3.0 days.
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