Goren: Anti-androgens may protect against severe COVID-19 outcomes: results from a prospective cohort study of 77 hospitalized men

Goren, 77 patient various antiandrogen late treatment study: 81% lower ICU admission [p=0.08] https://c19p.org/goren

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Anti-androgens may protect against severe COVID-19 outcomes: results from a prospective cohort study of 77 hospitalized men

Goren et al., Journal of the European Academy of Dermatology and Venereology, doi:10.1111/jdv.16953, NCT04368897 (history)

25 Sep 2020 Source PDF Share Tweet

Prospective study of 77 men hospitalized with COVID-19, 12 taking antiandrogens (9 dutasteride, 2 ﬁnasteride, 1 spironolactone), showing lower ICU admission with treatment (statistically significant with age-matched controls only when excluding the spironolactone patient). NCT04368897 (history).

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risk of ICU admission, 81.0% lower, RR 0.19, p = 0.08, treatment 1 of 12 (8.3%), control 17 of 36 (47.2%), NNT 2.6, adjusted per study, age-matched controls.

risk of ICU admission, 86.0% lower, RR 0.14, p = 0.04, treatment 1 of 12 (8.3%), control 38 of 65 (58.5%), NNT 2.0, adjusted per study, all controls.

risk of death, 50.0% higher, RR 1.50, p = 1.00, treatment 1 of 12 (8.3%), control 2 of 36 (5.6%), age-matched controls.

risk of death, 35.4% higher, RR 1.35, p = 0.58, treatment 1 of 12 (8.3%), control 4 of 65 (6.2%), all controls.

Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates

Goren et al., 25 Sep 2020, prospective, Brazil, peer-reviewed, 15 authors, trial NCT04368897 (history).

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Late treatment
is less effective

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