Yip, 88,962 patient molnupiravir early treatment study: 12% higher combined mortality/ICU admission [p=0.66] and 17% higher hospitalization [p=0.06] https://c19p.org/yip
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Impact of the Use of Oral Antiviral Agents on the Risk of Hospitalisation in Community COVID-19 Patients
et al., SSRN (Preprint)
Propensity score weighted retrospective of 93,883 outpatients in Hong Kong, 5,808 treated with molnupiravir and 4,921 treated with paxlovid, showing higher hospitalization and higher combined mortality/mechanical ventilation/ICU admission with molnupiravir, without statistical significance; and lower hospitalization and combined mortality/mechanical ventilation/ICU admission with paxlovid, statistically significant only for hospitalization.Concerns have been raised that the mutagenic mechanism of action may create dangerous variants or cause cancer [Hadj Hassine, Swanstrom].
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combined death/ventilation/ICU, 12.0% higher, HR 1.12, p = 0.66, treatment 53 of 5,808 (0.9%), control 151 of 83,154 (0.2%), propensity score weighting, Cox proportional hazards, day 30.
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risk of hospitalization, 17.0% higher, HR 1.17, p = 0.06, treatment 437 of 5,808 (7.5%), control 1,322 of 83,154 (1.6%), propensity score weighting, Cox proportional hazards, day 30.
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| Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates |
Yip et al., 5/24/2022, retrospective, placebo-controlled, China, preprint, 11 authors, study period 16 February, 2022 - 31 March, 2022.
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