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Home   COVID-19 treatment studies for Casirivimab/imdevimab  COVID-19 treatment studies for Casirivimab/i..  C19 studies: Casirivimab/i..  Casirivimab/i..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Oxygen therapy -21% Improvement Relative Risk Severe case -1% Hospitalization 14% c19early.com/r Williams et al. Casirivimab/i.. for COVID-19 LATE Favors casirivimab/im.. Favors control
Williams, 764 patient casirivimab/imdevimab early treatment study: 21% higher need for oxygen therapy [p=0.87], 1% higher severe cases [p=0.99], and 14% lower hospitalization [p=0.9] https://c19p.org/williams2
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Effectiveness of REGEN-COV combination monoclonal antibody infusion to reduce risk of COVID-19 hospitalization in pregnancy: A retrospective cohort study
Williams et al., American Journal of Obstetrics and Gynecology, doi:10.1016/j.ajog.2022.09.017
12 Sep 2022    Source   PDF   Share   Tweet
Retrospective 764 pregnant patients with COVID-19 in the USA, 88 treated with casirivimab/imdevimab, showing no significant difference in outcomes.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of oxygen therapy, 20.8% higher, RR 1.21, p = 0.87, treatment 1 of 88 (1.1%), control 6 of 676 (0.9%), odds ratio converted to relative risk.
risk of severe case, 1.0% higher, RR 1.01, p = 0.99, treatment 1 of 88 (1.1%), control 7 of 676 (1.0%), odds ratio converted to relative risk.
risk of hospitalization, 13.9% lower, RR 0.86, p = 0.90, treatment 1 of 88 (1.1%), control 8 of 676 (1.2%), NNT 2125, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Williams et al., 12 Sep 2022, retrospective, USA, peer-reviewed, 6 authors.
Contact: frank.williams2@ochsner.org.
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