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Home   COVID-19 treatment studies for Casirivimab/imdevimab  COVID-19 treatment studies for Casirivimab/i..  C19 studies: Casirivimab/i..  Casirivimab/i..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 50% Improvement Relative Risk Mortality (b) 67% Mortality (c) -2% Death/hospitalization 71% Death/hospitalization (b) 70% Recovery time 29% Recovery time (b) 29% c19regn.com Weinreich et al. NCT04425629 Casirivimab/i.. RCT EARLY Favors casirivimab/im.. Favors control
Weinreich, 4,180 patient casirivimab/imdevimab early treatment RCT: 71% lower combined mortality/hospitalization [p=0.001] and 29% faster recovery [p=0.001] https://c19p.org/weinreich
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REGEN-COV Antibody Combination and Outcomes in Outpatients with Covid-19
Weinreich et al., NEJM, doi:10.1056/NEJMoa2108163 (preprint 5/21/2021), NCT04425629 (history)
21 May 2021    Source   PDF   Share   Tweet
RCT 4,057 outpatients with >=1 risk factor for severe disease, showing significantly lower combined hospitalization/death, and significantly faster recovery with treatment. Median time from onset of symptoms 3 days. NCT04425629 (history).
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of death, 50.0% lower, RR 0.50, p = 0.45, treatment 2 of 2,091 (0.1%), control 4 of 2,089 (0.2%), NNT 1044, Table S9.
risk of death, 67.0% lower, RR 0.33, p = 0.37, treatment 1 of 1,355 (0.1%), control 3 of 1,341 (0.2%), NNT 667, 2400mg,Table S9.
risk of death, 1.6% higher, RR 1.02, p = 1.00, treatment 1 of 736 (0.1%), control 1 of 748 (0.1%), 1200mg,Table S9.
risk of death/hospitalization, 71.3% lower, RR 0.29, p < 0.001, treatment 18 of 1,355 (1.3%), control 62 of 1,341 (4.6%), NNT 30, 2400mg.
risk of death/hospitalization, 70.4% lower, RR 0.30, p = 0.002, treatment 7 of 736 (1.0%), control 24 of 748 (3.2%), NNT 44, 1200mg.
recovery time, 28.6% lower, relative time 0.71, p < 0.001, treatment 1,355, control 1,341, 2400mg.
recovery time, 28.6% lower, relative time 0.71, p < 0.001, treatment 736, control 748, 1200mg.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Weinreich et al., 21 May 2021, Randomized Controlled Trial, USA, peer-reviewed, 39 authors, average treatment delay 3.0 days, trial NCT04425629 (history).
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