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c19early.org COVID-19 treatment researchTixagevimab/cilgavimabTixagev../c.. (more..)
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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Severe case 26% Improvement Relative Risk Tixagevimab/c..  Solera et al.  Prophylaxis Is prophylaxis with tixagevimab/cilgavimab beneficial for COVID-19? Retrospective 1,975 patients in Canada Lower severe cases with tixagevimab/cilgavimab (not stat. sig., p=0.48) c19early.org Solera et al., American J. Transplanta.., Mar 2024 Favors tixagevimab/ci.. Favors control

Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023

Solera et al., American Journal of Transplantation, doi:10.1016/j.ajt.2024.03.011
Mar 2024  
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36th treatment shown to reduce risk in May 2022
 
*, now known with p = 0.000013 from 16 studies, recognized in 30 countries. Efficacy is variant dependent.
Lower risk for mortality, hospitalization, and cases.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 1,975 solid organ transplant recipients with COVID-19 showing lower risk of severe cases with tixagevimab/cilgavimab prophylaxis, without statistical significance.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2.75.2, BA.4.6, BQ.1.1 Planas, BA.5, BA.2.75, XBB Haars, ХВВ.1.9.1, XBB.1.9.3, XBB.1.5.24, XBB.1.16, XBB.2.9, BQ.1.1.45, CL.1, and CH.1.1 Pochtovyi.
risk of severe case, 25.6% lower, RR 0.74, p = 0.48, treatment 7 of 156 (4.5%), control 283 of 1,819 (15.6%), NNT 9.0, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Solera et al., 31 Mar 2024, retrospective, Canada, peer-reviewed, median age 57.5, 12 authors. Contact: jtsolera@gmail.com, deepali.kumar@uhn.ca.
This PaperTixagev../c..All
Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023
Javier T Solera, Berta G Árbol, Ankit Mittal, Victoria Hall, Tina Marinelli, Ilona Bahinskaya, Nazia Selzner, Michael Mcdonald, Jeffrey Schiff, Aman Sidhu, Atul Humar, Deepali Kumar
American Journal of Transplantation, doi:10.1016/j.ajt.2024.03.011
solid organ transplant outcomes vaccination mRNA vaccines antivirals bivalent booster vaccines remdesivir
Declaration of competing interest Deepali Kumar has received clinical trial grants from GSK, Roche, and consultancy fees from GSK, Roche, Merck, Takeda, Exevir, and Allovir. Atul Humar has received clinical trial grants from Merck and consultancy fees from Merck and Takeda. The other authors have no conflicts of interest to disclose. Appendix A. Supplementary data Supplementary data to this article can be found online at https://doi.org/10.1016/j.ajt.2024.03.011.
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'article-title': 'COVID-19 in solid organ transplant recipients: initial report from the ' 'US epicenter', 'author': 'Pereira', 'doi-asserted-by': 'crossref', 'first-page': '1800', 'issue': '7', 'journal-title': 'Am J Transplant', 'key': '10.1016/j.ajt.2024.03.011_bib28', 'volume': '20', 'year': '2020'}, { 'DOI': '10.1111/tid.13650', 'article-title': 'Immunosuppression in solid organ transplant recipients with Covid-19: ' 'more data, but still complicated', 'author': 'Heldman', 'doi-asserted-by': 'crossref', 'issue': '4', 'journal-title': 'Transpl Infect Dis', 'key': '10.1016/j.ajt.2024.03.011_bib29', 'volume': '23', 'year': '2021'}, { 'DOI': '10.1111/ajt.16840', 'article-title': 'Changing trends in mortality among solid organ transplant recipients ' 'hospitalized for COVID-19 during the course of the pandemic', 'author': 'Heldman', 'doi-asserted-by': 'crossref', 'first-page': '279', 'issue': '1', 'journal-title': 'Am J Transplant', 'key': '10.1016/j.ajt.2024.03.011_bib30', 'volume': '22', 'year': '2022'}, { 'DOI': '10.1111/ajt.17128', 'article-title': 'Tixagevimab/cilgavimab pre-exposure prophylaxis is associated with ' 'lower breakthrough infection risk in vaccinated solid organ transplant ' 'recipients during the omicron wave', 'author': 'Al Jurdi', 'doi-asserted-by': 'crossref', 'first-page': '3130', 'issue': '12', 'journal-title': 'Am J Transplant', 'key': '10.1016/j.ajt.2024.03.011_bib31', 'volume': '22', 'year': '2022'}, { 'DOI': '10.1016/j.kint.2022.07.008', 'article-title': 'COVID-19 morbidity decreases\xa0with tixagevimab-cilgavimab preexposure ' 'prophylaxis in kidney transplant recipient nonresponders or low-vaccine ' 'responders', 'author': 'Kaminski', 'doi-asserted-by': 'crossref', 'first-page': '936', 'issue': '4', 'journal-title': 'Kidney Int', 'key': '10.1016/j.ajt.2024.03.011_bib32', 'volume': '102', 'year': '2022'}], 'reference-count': 31, 'references-count': 31, 'relation': {}, 'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1600613524002077'}}, 'score': 1, 'short-container-title': ['American Journal of Transplantation'], 'short-title': [], 'source': 'Crossref', 'subject': [], 'subtitle': [], 'title': ['Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023'], 'type': 'journal-article', 'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy'}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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