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Metformin study #9   All Outcomes
0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 30% Imp. Relative Risk, 95% CI Ravindra: Retrospective Assessment of Treatments of Hospitalized C.. c19early.com/ravindra.html Favors metformin Favors control
5/5 Prophylaxis study
Ravindra et al., medRxiv, doi:10.1101/2021.04.20.21255792 (Peer Reviewed)
Retrospective Assessment of Treatments of Hospitalized Covid-19 Patients
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Retrospective 1,035 hospitalized patients in India. Of 366 diabetic patients, there was lower mortality for the 53 that were on metformin.
risk of death, 29.6% lower, RR 0.70, p = 0.42, treatment 5 of 53 (9.4%), control 57 of 313 (18.2%), adjusted per study, odds ratio converted to relative risk.
This study is excluded in the after exclusion results of meta analysis: minimal details provided.
Ravindra et al., 5/5/2021, retrospective, India, South Asia, peer-reviewed, 14 authors.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. For an individual study the most serious outcome may have a smaller number of events and lower statistical significance, however this provides the strongest evidence for the most serious outcomes when combining the results of many trials.
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