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Home   COVID-19 treatment studies for Acetaminophen  COVID-19 treatment studies for Acetaminophen  C19 studies: Acetaminophen  Acetaminophen   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Recovery -43% Improvement Relative Risk Progression -3925% Recovery time -133% Recovery time (b) -75% Recovery time (c) -75% Viral clearance -20% c19early.com/ace Ravichandran et al. CTRI/2021/05/033544 Acetaminophen RCT LATE Favors acetaminophen Favors indomethacin
Ravichandran, 210 patient acetaminophen late treatment RCT: 43% worse recovery [p=0.002], 3925% higher progression [p<0.0001], and 20% worse viral clearance [p=0.19] https://c19p.org/ravichandranace
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An open label randomized clinical trial of Indomethacin for mild and moderate hospitalised Covid-19 patients
Ravichandran et al., Scientific Reports, doi:10.1038/s41598-022-10370-1, CTRI/2021/05/033544
19 Apr 2022    Source   PDF   Share   Tweet
RCT with 107 paracetamol and 103 indomethacin patients, showing higher progression and worse recovery with paracetamol.
risk of no recovery, 42.5% higher, RR 1.43, p = 0.002, treatment 77 of 107 (72.0%), control 52 of 103 (50.5%), day 14.
risk of progression, 3925.2% higher, RR 40.25, p < 0.001, treatment 20 of 107 (18.7%), control 0 of 103 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), SpO2 ≤93.
recovery time, 133.3% higher, relative time 2.33, p < 0.001, treatment median 7.0 IQR 2.75 n=107, control median 3.0 IQR 1.0 n=103, fever.
recovery time, 75.0% higher, relative time 1.75, p < 0.001, treatment median 7.0 IQR 2.0 n=107, control median 4.0 IQR 2.0 n=103, myalgia.
recovery time, 75.0% higher, relative time 1.75, p < 0.001, treatment median 7.0 IQR 3.0 n=107, control median 4.0 IQR 1.0 n=103, cough.
risk of no viral clearance, 20.1% higher, RR 1.20, p = 0.19, treatment 43 of 60 (71.7%), control 37 of 62 (59.7%), day 7.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ravichandran et al., 19 Apr 2022, Randomized Controlled Trial, India, peer-reviewed, 8 authors, this trial compares with another treatment - results may be better when compared to placebo, trial CTRI/2021/05/033544.
Contact: rkkumar@iitm.ac.in.
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Late treatment
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