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0 0.5 1 1.5 2+ Mortality 52% Improvement Relative Risk c19early.com/na Pellegrini et al. N-acetylcys.. for COVID-19 LATE Favors N-acetylcysteine Favors control
Pellegrini, 864 patient N-acetylcysteine late treatment study: 52% lower mortality [p=0.0001] https://c19p.org/pellegrini
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A Retrospective Analysis of Outcomes Amongst COVID-19 Infected Patients with Acute Hepatitis Receiving N-Acetylcysteine Therapy in a Safety Net Hospital
Pellegrini et al., Gastroenterology, doi:10.1016/S0016-5085(21)02756-6
23 May 2021    Source   PDF   Share   Tweet
Retrospective 864 hospitalized late stage COVID-19 patients in the USA, 138 receiving NAC treatment for acute hepatitis, showing lower mortality with treatment. Results are adjusted for confounders, however details are not provided.
risk of death, 51.7% lower, OR 0.48, p < 0.001, treatment 138, control 726, adjusted per study, inverted to make OR<1 favor treatment, multivariable, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Pellegrini et al., 23 May 2021, retrospective, USA, peer-reviewed, 10 authors, study period March 2020 - May 2020.
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Late treatment
is less effective
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