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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ Mortality 75% Improvement Relative Risk c19early.com/luo3.html Favors metformin Favors control
21 May 2020 - Prophylaxis study
Metformin Treatment Was Associated with Decreased Mortality in COVID-19 Patients with Diabetes in a Retrospective Analysis
Luo et al., The American Journal of Tropical Medicine and Hygiene, doi:10.4269/ajtmh.20-0375 (Peer Reviewed)
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Retrospective 283 COVID-19+ diabetes patients in China, showing lower mortality with existing metformin treatment.
risk of death, 74.7% lower, RR 0.25, p = 0.02, treatment 3 of 104 (2.9%), control 22 of 179 (12.3%), NNT 11, adjusted per study, odds ratio converted to relative risk, multivariate.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Luo et al., 5/21/2020, retrospective, China, Asia, peer-reviewed, 9 authors.
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