Retrospective 283 COVID-19+ diabetes patients in China, showing lower mortality with existing metformin treatment.
Luo et al., 5/21/2020, retrospective, China, Asia, peer-reviewed, 9 authors.
risk of death, 74.7% lower, RR 0.25, p = 0.02, treatment 3 of 104 (2.9%), control 22 of 179 (12.3%), adjusted per study, odds ratio converted to relative risk, multivariate.
Effect extraction follows pre-specified rules
prioritizing more serious outcomes. For an individual study the most serious
outcome may have a smaller number of events and lower statistical signficance,
however this provides the strongest evidence for the most serious outcomes
when combining the results of many trials.