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0 0.5 1 1.5 2+ Mortality 78% Improvement Relative Risk Ventilation -27% c19early.com/mf Li et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
Li, 131 patient metformin prophylaxis study: 78% lower mortality [p=0.02] https://c19p.org/li12
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Metformin Use in Diabetes Prior to Hospitalization: Effects on Mortality in Covid-19
Li et al., Endocrine Practice, doi:10.4158/EP-2020-0466
1 Oct 2020    Source   PDF   Share   Tweet
Retrospective 131 type II diabetes patients with COVID pneumonia, showing lower mortality with existing metformin use. Acarbose (commonly used in China as an initial therapy for diabetes) did not have a similar association with mortality, suggesting that the result may not be explained by metformin being used early in type II diabetes.
risk of death, 77.7% lower, HR 0.22, p = 0.02, treatment 2 of 37 (5.4%), control 21 of 94 (22.3%), NNT 5.9, adjusted per study, multivariable.
risk of mechanical ventilation, 27.0% higher, RR 1.27, p = 1.00, treatment 1 of 37 (2.7%), control 2 of 94 (2.1%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Li et al., 10/1/2020, retrospective, China, Asia, peer-reviewed, 16 authors, study period 23 January, 2020 - 19 March, 2020.
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