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Home   COVID-19 treatment studies for Tixagevimab/cilgavimab  COVID-19 treatment studies for Tixagev../c..  C19 studies: Tixagev../c..  Tixagev../c..   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality 86% Improvement Relative Risk Symptomatic case 76% c19early.com/tc Levin et al. NCT04625725 Tixagev../c.. RCT Prophylaxis Favors tixagevimab/ci.. Favors control
Levin, 5,172 patient tixagevimab/cilgavimab prophylaxis RCT: 86% lower mortality [p=0.11] and 76% fewer symptomatic cases [p=0.0005] https://c19p.org/levin
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PROVENT: Phase 3 Study of Efficacy and Safety of AZD7442 (Tixagevimab/Cilgavimab) for Pre-exposure Prophylaxis of COVID-19 in Adults
Levin et al., Open Forum Infectious Diseases, doi:10.1093/ofid/ofab466.1646 (Preprint)
8 Dec 2021    Source   PDF   Share   Tweet
PrEP RCT with 3,441 tixagevimab/cilgavimab patients and 1,731 control patients, showing lower risk of symptomatic cases with treatment. Followup data is from [fda.gov]. PROVENT. NCT04625725.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2 [Zhou].
risk of death, 85.7% lower, RR 0.14, p = 0.11, treatment 0 of 3,441 (0.0%), control 2 of 1,731 (0.1%), NNT 866, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of symptomatic case, 76.3% lower, RR 0.24, p < 0.001, treatment 8 of 3,441 (0.2%), control 17 of 1,731 (1.0%), NNT 133.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Levin et al., 12/8/2021, Double Blind Randomized Controlled Trial, placebo-controlled, multiple countries, multiple regions, preprint, 19 authors, trial NCT04625725.
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