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0 0.5 1 1.5 2+ Recovery, dyspnea 89% Improvement Relative Risk Recovery, anosmia 95% Recovery, fatigue 94% Recovery, myalgia -388% Recovery, headache -194% Recovery, cough 9% c19vitaminc.com Kumar et al. CTRI/2021/06/034254 Vitamin C RCT EARLY Favors vitamin C Favors control
Kumar, 192 patient vitamin C early treatment RCT: 89% improved recovery [p=0.05] https://c19p.org/kumar3c
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Efficacy and Safety of Aspirin, Promethazine, and Micronutrients for Rapid Clinical Recovery in Mild to Moderate COVID-19 Patients: A Randomized Controlled Clinical Trial
Kumar et al., Cureus, doi:10.7759/cureus.25467, CTRI/2021/06/034254
30 May 2022    Source   PDF   Share   Tweet
RCT 260 patients in India, 130 treated with aspirin, promethazine, vitamin C, D, B3, zinc, and selenium, showing faster recovery with treatment. There was no hospitalization, ICU admission, or supplemental oxygen requirements in either group.
risk of no recovery, 89.2% lower, RR 0.11, p = 0.05, treatment 0 of 99 (0.0%), control 4 of 93 (4.3%), NNT 23, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 10, dyspnea.
risk of no recovery, 95.4% lower, RR 0.05, p < 0.001, treatment 0 of 99 (0.0%), control 10 of 93 (10.8%), NNT 9.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 10, anosmia.
risk of no recovery, 94.3% lower, RR 0.06, p = 0.003, treatment 0 of 99 (0.0%), control 8 of 93 (8.6%), NNT 12, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 10, fatigue.
risk of no recovery, 387.9% higher, RR 4.88, p = 0.50, treatment 2 of 99 (2.0%), control 0 of 93 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 10, myalgia.
risk of no recovery, 193.9% higher, RR 2.94, p = 1.00, treatment 1 of 99 (1.0%), control 0 of 93 (0.0%), continuity correction due to zero event (with reciprocal of the contrasting arm), day 10, headache.
risk of no recovery, 8.5% lower, RR 0.91, p = 0.66, treatment 37 of 99 (37.4%), control 38 of 93 (40.9%), NNT 29, day 10, cough.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Kumar et al., 30 May 2022, Randomized Controlled Trial, India, peer-reviewed, mean age 36.0, 8 authors, study period December 2021 - February 2022, this trial uses multiple treatments in the treatment arm (combined with aspirin, promethazine, vitamin D, B3, zinc, and selenium) - results of individual treatments may vary, trial CTRI/2021/06/034254.
Contact: vgvclinical@gmail.com.
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