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0 0.5 1 1.5 2+ Mortality 1% Improvement Relative Risk c19hcq.com Ip et al. HCQ for COVID-19 LATE TREATMENT Favors HCQ Favors control
Ip, 2,512 patient HCQ late treatment study: 1% lower mortality [p=0.93] https://c19p.org/ip2
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Hydroxychloroquine and Tocilizumab Therapy in COVID-19 Patients - An Observational Study
25 May 2020    Source   PDF   Share   Tweet
Retrospective study of late stage use on 2,512 hospitalized patients showing no significant differences in associated mortality for patients receiving any HCQ during the hospitalization (HR, 0.99 [95% CI, 0.80-1.22]), HCQ alone (HR, 1.02 [95% CI, 0.83-1.27]), or HCQ+AZ (HR, 0.98 [95% CI, 0.75-1.28]). Misclassification is possible due to manual abstraction of EHR data. They observed a change in the prescribing patterns of HCQ during the study timeframe. Confounding by indication.
risk of death, 1.0% lower, HR 0.99, p = 0.93, treatment 432 of 1,914 (22.6%), control 115 of 598 (19.2%), adjusted per study.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ip et al., 5/25/2020, retrospective, database analysis, USA, North America, peer-reviewed, 32 authors, average treatment delay 5.0 days.
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Late treatment
is less effective
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