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0 0.5 1 1.5 2+ NEWS2 score 77% Improvement Relative Risk Oxygen therapy 92% Oxygen time 70% Hospitalization time 13% Viral clearance 10% c19vitaminc.com Hellou et al. NCT04382040 Vitamin C RCT LATE TREATMENT Favors vitamin C Favors control
Hellou, 50 patient vitamin C late treatment RCT: 77% improved recovery [p=0.04], 92% lower need for oxygen therapy [p=0.01], 13% shorter hospitalization [p=0.92], and 10% improved viral clearance [p=0.77] https://c19p.org/hellouc
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Effect of ArtemiC in patients with COVID-19: A Phase II prospective study
Hellou et al., Journal of Cellular and Molecular Medicine, doi:10.1111/jcmm.17337, NCT04382040 (history)
19 May 2022    Source   PDF   Share   Tweet
RCT 50 hospitalized patients in Israel, 33 treated with curcumin, vitamin C, artemisinin, and frankincense oral spray, showing improved recovery with treatment.
relative NEWS2 score, 76.7% better, RR 0.23, p = 0.04, treatment mean 0.52 (±0.67) n=33, control mean 2.23 (±3.2) n=17, day 15.
risk of oxygen therapy, 92.2% lower, RR 0.08, p = 0.01, treatment 0 of 33 (0.0%), control 4 of 17 (23.5%), NNT 4.2, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), day 15.
oxygen time, 69.7% lower, relative time 0.30, p = 0.17, treatment mean 2.3 (±1.4) n=33, control mean 7.6 (±4.6) n=17.
hospitalization time, 13.3% lower, relative time 0.87, p = 0.92, treatment mean 7.8 (±7.3) n=33, control mean 9.0 (±8.0) n=17.
risk of no viral clearance, 9.8% lower, RR 0.90, p = 0.77, treatment 14 of 33 (42.4%), control 8 of 17 (47.1%), NNT 22, day 15.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Hellou et al., 19 May 2022, Double Blind Randomized Controlled Trial, placebo-controlled, Israel, peer-reviewed, 6 authors, this trial uses multiple treatments in the treatment arm (combined with curcumin, artemisinin, and frankincense) - results of individual treatments may vary, trial NCT04382040 (history).
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