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0 0.5 1 1.5 2+ Mortality 95% Improvement Relative Risk Progression 39% Progression (b) 33% Hospitalization 56% c19early.com/pl Ganatra et al. Paxlovid for COVID-19 EARLY TREATMENT Favors paxlovid Favors control
Ganatra, 2,260 patient paxlovid early treatment PSM study: 95% lower mortality [p=0.002], 39% lower progression [p=0.0001], and 56% lower hospitalization [p=0.02] https://c19p.org/ganatra
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Oral Nirmatrelvir and Ritonavir in Non-hospitalized Vaccinated Patients with Covid-19
Ganatra et al., Clinical Infectious Diseases, doi:10.1093/cid/ciac673
20 Aug 2022    Source   PDF   Share   Tweet
TriNetX retrospective 1,131 vaccinated COVID-19 patients treated with paxlovid and matched controls, showing lower mortality and hospitalization with treatment.
risk of death, 95.2% lower, RR 0.05, p = 0.002, treatment 0 of 1,130 (0.0%), control 10 of 1,130 (0.9%), NNT 113, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm), propensity score matching, day 30.
risk of progression, 39.2% lower, RR 0.61, p < 0.001, treatment 89 of 1,130 (7.9%), control 163 of 1,130 (14.4%), NNT 15, odds ratio converted to relative risk, combined ER/hospitalization/death, propensity score matching, day 30.
risk of progression, 32.9% lower, HR 0.67, p = 0.003, treatment 89 of 1,130 (7.9%), control 163 of 1,130 (14.4%), combined ER/hospitalization/death, propensity score matching, Kaplan–Meier, day 30.
risk of hospitalization, 56.5% lower, RR 0.44, p = 0.02, treatment 10 of 1,130 (0.9%), control 23 of 1,130 (2.0%), NNT 87, odds ratio converted to relative risk, propensity score matching, day 30.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ganatra et al., 20 Aug 2022, retrospective, USA, peer-reviewed, mean age 57.6, 9 authors, study period 1 December, 2021 - 18 April, 2022.
Contact: sarju.ganatra@lahey.org.
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