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0 0.5 1 1.5 2+ ICU admission 89% Improvement Relative Risk Oxygen therapy 85% Hospitalization 75% c19regn.com Bierle et al. Casirivimab/i.. for COVID-19 EARLY Favors casirivimab/im.. Favors control
Bierle, 1,395 patient casirivimab/imdevimab early treatment study: 89% lower ICU admission [p=0.16], 85% lower need for oxygen therapy [p<0.0001], and 75% lower hospitalization [p<0.0001] https://c19p.org/bierle
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Monoclonal Antibody Treatment of Breakthrough COVID-19 in Fully Vaccinated Individuals with High-Risk Comorbidities
Bierle et al., The Journal of Infectious Diseases, doi:10.1093/infdis/jiab570 (preprint 10/20/2021)
20 Oct 2021    Source   PDF   Share   Tweet
Retrospective 1,395 vaccinated COVID-19 cases, showing significantly lower hospitalization and oxygen supplementation with monoclonal antibody treatment, primarily casirivimab-imdevimab. Hospitalization was significantly associated with comorbidities.
Efficacy is variant dependent. Unlikely to be effective for omicron [Liu, Sheward, Tatham, VanBlargan].
risk of ICU admission, 88.9% lower, RR 0.11, p = 0.16, treatment 0 of 527 (0.0%), control 5 of 868 (0.6%), NNT 174, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of oxygen therapy, 85.3% lower, RR 0.15, p < 0.001, treatment 5 of 527 (0.9%), control 56 of 868 (6.5%), NNT 18, odds ratio converted to relative risk.
risk of hospitalization, 75.3% lower, RR 0.25, p < 0.001, treatment 14 of 527 (2.7%), control 93 of 868 (10.7%), NNT 12, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
This study is excluded in meta analysis: patients were treated with different medications, results specific to each medication were not reported.
Conflicts of interest: research funding from the drug patent holder.
Bierle et al., 10/20/2021, retrospective, USA, North America, peer-reviewed, 7 authors, average treatment delay 5.0 days.
Contact: razonable.raymund@mayo.edu.
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