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All Studies   All Outcomes   Recent: 
0 0.5 1 1.5 2+ Mortality 6% Improvement Relative Risk 7-point scale 10% 7-point scale (b) -2% c19rmd.com Ader et al. NCT04315948 DISCOVERY Remdesivir RCT LATE Favors remdesivir Favors control
Ader, 832 patient remdesivir late treatment RCT: 6% lower mortality [p=0.77] and 10% improved 7-point scale results [p=0.39] https://c19p.org/ader
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Remdesivir plus standard of care versus standard of care alone for the treatment of patients admitted to hospital with COVID-19 (DisCoVeRy): a phase 3, randomised, controlled, open-label trial
Ader et al., Lancet Infectious Diseases, doi:10.1016/S1473-3099(21)00485-0, DISCOVERY, NCT04315948 (history)
14 Sep 2021    Source   PDF   Share   Tweet
RCT 857 hospitalized patients, showing no significant differences with remdesivir treatment. EudraCT2020-000936-23.
[Gérard, Zhou] show significantly increased risk of acute kidney injury with remdesivir.
risk of death, 6.4% lower, RR 0.94, p = 0.77, treatment 34 of 414 (8.2%), control 37 of 418 (8.9%), NNT 156, adjusted per study, odds ratio converted to relative risk, 28 days.
risk of 7-point scale, 9.9% lower, OR 0.90, p = 0.39, treatment 414, control 418, inverted to make OR<1 favor treatment, 28 days, RR approximated with OR.
risk of 7-point scale, 2.0% higher, OR 1.02, p = 0.85, treatment 414, control 418, inverted to make OR<1 favor treatment, 15 days, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ader et al., 14 Sep 2021, Randomized Controlled Trial, multiple countries, peer-reviewed, 17 authors, average treatment delay 9.0 days, trial NCT04315948 (history) (DISCOVERY).
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This PaperRemdesivirAll
Late treatment
is less effective
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