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Paxlovid study #2   All Outcomes
11/5 Animal
Abdelnabi et al., bioRxiv, doi:10.1101/2021.11.04.467077 (Preprint)
The oral protease inhibitor (PF-07321332) protects Syrian hamsters against infection with SARS-CoV-2 variants of concern
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In Vitro and hamster study showing paxlovid component PF-07321332 effective against four variants of concern, inibits replication of the alpha variant in primary human airway epithelial cells, protected Syrian hamsters against intranasal infection with B.1.351 and B.1.617.2, and prevented transmission from B.1.617.2 infected animals.
Abdelnabi et al., 11/5/2021, preprint, 17 authors.
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