Retrospective 4,445 COVID+ patients in China, showing higher risk of combined death/intubation/ICU with famotidine treatment.
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risk of severe case, 81.0% higher, HR 1.81, p < 0.001, treatment 72 of 519 (13.9%), control 198 of 2,595 (7.6%), death/intubation/ICU, propensity score matching, Cox proportional hazards.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Zhou et al., 4 Dec 2020, retrospective, propensity score matching, China, peer-reviewed, 7 authors, study period 1 January, 2020 - 22 August, 2020.
Upregulation of enteric alpha-synuclein as a possible link between inflammatory bowel disease and Parkinson’s disease
Pascal Derkinderen, Wendy Noble, Michel Neunlist, Malvyne Rolli-Derkinderen
Gut, doi:10.1136/gutjnl-2020-323482
PostScript Figure 1 Kaplan-Meier curve stratified by proton pump inhibitor (PPI) use before and after propensity score matching. Figure 2 Kaplan-Meier curve stratified by famotidine use before and after propensity score matching. Provenance and peer review Not commissioned; externally peer reviewed.
Competing interests None declared.
Patient consent for publication Not required. ethics approval This study was approved by the Institutional Review Board of the University of Hong Kong/Hospital Authority Hong Kong West Cluster. Provenance and peer review Not commissioned; internally peer reviewed.
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