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Home   COVID-19 treatment studies for Vitamin C  COVID-19 treatment studies for Vitamin C  C19 studies: Vitamin C  Vitamin C   Select treatmentSelect treatmentTreatmentsTreatments
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0 0.5 1 1.5 2+ Mortality -157% Improvement Relative Risk Mortality (b) -169% Clinical improvement ≥.. -35% Clinical improvemen.. (b) -32% c19early.com/c Zheng et al. Vitamin C for COVID-19 LATE TREATMENT Favors vitamin C Favors control
Zheng, 397 patient vitamin C late treatment PSM study: 157% higher mortality [p=0.33] and 35% worse improvement [p=0.17] https://c19p.org/zheng
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No significant benefit of moderate-dose vitamin C on severe COVID-19 cases
Zheng et al., Open Medicine, doi:10.1515/med-2021-0361
22 Sep 2021    Source   PDF   Share   Tweet
Retrospective 397 severe COVID-19 patients in China, showing worse outcomes with vitamin C treatment, without statistical significance. IV vitamin C 2-4g/day. Subject to confounding by indication and immortal time bias. Exclusion criteria were (a) the duration of hospitalization was less than 3 days; (b) vitamin C treatment started before admission; and (c) the length of vitamin C use was less than 3 days. Includes vitamin C use started at any time during hospitalization, for many patients this was >15 days later (Figure A2). Duration of treatment varied widely (Figure A1). Treatment was determined by clinicians according to the condition of each patient.
risk of death, 157.0% higher, HR 2.57, p = 0.33, treatment 12 of 70 (17.1%), control 7 of 327 (2.1%), adjusted per study, propensity score matching.
risk of death, 169.0% higher, HR 2.69, p = 0.07, treatment 12 of 70 (17.1%), control 7 of 327 (2.1%), adjusted per study, IPTW.
clinical improvement ≥ 2 points, 35.1% worse, HR 1.35, p = 0.17, treatment 18 of 70 (25.7%), control 16 of 327 (4.9%), adjusted per study, inverted to make RR<1 favor treatment, propensity score matching.
clinical improvement ≥ 2 points, 31.6% worse, HR 1.32, p = 0.11, treatment 18 of 70 (25.7%), control 16 of 327 (4.9%), adjusted per study, inverted to make RR<1 favor treatment, IPTW.
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This study is excluded in the after exclusion results of meta analysis: substantial unadjusted confounding by indication likely, immortal time bias may significantly affect results, treatment start times unknown, treatment may not have started at baseline.
Zheng et al., 22 Sep 2021, retrospective, China, peer-reviewed, 10 authors, study period 13 February, 2020 - 29 February, 2020.
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