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0 0.5 1 1.5 2+ Mortality -23% Improvement Relative Risk Mortality (b) 17% c19early.com/ib Wong et al. Ibuprofen for COVID-19 Prophylaxis Favors ibuprofen Favors control
Wong, 1,977,972 patient ibuprofen prophylaxis study: 23% higher mortality [p=0.19] https://c19p.org/wong4ib
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Use of non-steroidal anti-inflammatory drugs and risk of death from COVID-19: an OpenSAFELY cohort analysis based on two cohorts
Wong et al., Annals of the Rheumatic Diseases, doi:10.1136/annrheumdis-2020-219517
21 Jan 2021    Source   PDF   Share   Tweet
Retrospective 2,463,707 people in the UK, showing no significant difference in COVID-19 mortality with NSAID use. Current NSAID users were defined as those ever prescribed an NSAID in the 4 months prior to study start, and non-users were those with no record of NSAID prescription in the same time period.
risk of death, 23.0% higher, HR 1.23, p = 0.19, adjusted per study, general population, multivariable.
risk of death, 17.0% lower, HR 0.83, p = 0.37, adjusted per study, rheumatoid arthritis/osteoarthritis patients, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wong et al., 21 Jan 2021, retrospective, United Kingdom, peer-reviewed, median age 53.0, 32 authors, study period 1 March, 2020 - 14 June, 2020.
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