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0 0.5 1 1.5 2+ Mortality 28% Improvement Relative Risk Discharge 15% c19early.com/mf Wargny et al. NCT04324736 CORONADO Metformin Prophylaxis Favors metformin Favors control
Wargny, 2,794 patient metformin prophylaxis study: 28% lower mortality [p=0.03] and 15% higher hospital discharge [p=0.02] https://c19p.org/wargny
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Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study
Wargny et al., Diabetologia, doi:10.1007/s00125-020-05351-w, CORONADO, NCT04324736 (history)
17 Feb 2021    Source   PDF   Share   Tweet
Retrospective 2,796 hospitalized diabetes patients with COVID-19 in France, showing lower mortality with metformin use.
risk of death, 28.3% lower, RR 0.72, p = 0.03, treatment 247 of 1,553 (15.9%), control 330 of 1,241 (26.6%), NNT 9.4, adjusted per study, odds ratio converted to relative risk, multivariable, day 28.
risk of no hospital discharge, 14.8% lower, RR 0.85, p = 0.02, treatment 690 of 1,553 (44.4%), control 702 of 1,241 (56.6%), NNT 8.2, adjusted per study, inverted to make RR<1 favor treatment, odds ratio converted to relative risk, multivariable, day 28.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Wargny et al., 17 Feb 2021, retrospective, France, peer-reviewed, 43 authors, study period 10 March, 2020 - 10 April, 2020, trial NCT04324736 (history) (CORONADO).
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