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0 0.25 0.5 0.75 1 1.25 1.5 1.75 2+ ICU admission 12% Improvement Relative Risk c19early.com/wang5.html Favors metformin Favors control
7 September 2021 - Prophylaxis study
Evaluation and management of COVID-19-related severity in people with type 2 diabetes
Wang et al., BMJ Open Diabetes Research & Care, doi:10.1136/bmjdrc-2021-002299 (Peer Reviewed)
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Retrospective 16,504 COVID-19 type 2 diabetes patients, showing lower risk of ICU admission with existing metformin use.
risk of ICU admission, 12.0% lower, RR 0.88, p = 0.005, treatment 6,504, control 10,000, Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes.
Wang et al., 9/7/2021, retrospective, USA, North America, peer-reviewed, 4 authors.
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